LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & BIOTECHNOLOGY
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SIXTH SEMESTER – APRIL 2006
PB 6600 – IMMUNOLOGY & IMMUNOTECHNOLOGY
(Also equivalent to PBB 600)
Date & Time : 26-04-2006/9.00-12.00 Dept. No. Max. : 100 Marks
Part A
Answer all the following questions (20 marks)
- Choose the correct answer (5 x 1 = 5 )
- Pick out the wrong pair.
- a) Yalow-ELISA b) Metchnikoff – phagocytosis
- c) Jenner- vaccination d) Kitasato – tetanus toxin.
- Which among the following can cross the placenta.
- a) IgD b) IgG c) IgA d) IgE
- Ouchterloy test is associated with .
- a) agglutination b) opsonization c) nertralization d) precipitation
- NK cells refers to _______ cells .
- a) neutral killer b) natural killer c) native killer d) naive killer
- In hybridoma technology _______ cells are made to fuse with spleen cells.
- a) myogenic b) myeloma c) myopia d) maternal
- State whether the following statements are True or False (5 x 1 = 5 )
- Pasteur coined the term vaccination .
- Haptens are otherwise known as partial antibodies.
- Schick test is associated with toxin – antitoxin reactions.
- B cells have their origin from bone marrow.
- Polyclonal antibodies have many antigenic determinants.
III. Complete the following (5 x 1 = 5)
- ________ _________were first reported by Kohler and Milstein.
- _____ are the only antibodies which can cross the placenta
- IgM is also called _________.
- Wasserman test is used in the diagnosis of ________.
- Lymphokines come under ________.
- Answer the following in one or two sentences. (5 x 1 = 5)
- Mention the contribution of Tonegawa to the field of immunology.
- Distinguish between allotype and isotype.
- What are the features of Forsmann antigens ?
- What are interferons ?
- Expand HAT medium.
Part B
Answer any five of the following each in about 350 words. (5 x 8 = 40)
- Write about the scope of immunology.
- Give an outline of immunity.
- Write down the characteristics of antigens.
- Draw diagrams only of a typical Ig molecule. Why it is said to be bifunctional ?
- Bring out the differences between T cells and B cells.
- Expand the following with a footnote :
- a) BCG b) ARS c) CFT d) HGPRT
- Write about the central lymphoid organs.
- Discuss the applications of polyclonal antibodies.
Part C
Answer the following questions in about 1500 words. Draw necessary diagrams (2 x 20 = 40)
- a) What are cytokines ?. Mention their properties, types and role in immunity.
OR
- Discuss the production of monoclonal antibodies .
- a) Write about any 2 antigen- antibody reactions.
OR
- Write short notes on :
- IgE ii. Phagocytosis iii. inflammation
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